Reducing door-to-wire time for ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention by multidisciplinary collaboration: An observational study

The aim of this study is to reduce door-to-wire time for ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention through multidisciplinary collaboration. Patients over the age of 18who visited the Foshan Sanshui District People’s Hospital between 2018 and 2019 and were diagnosed with STEMI were included in this study. Analyses were performed with patients segregated into a pre-intervention interim period (2018) and a post-intervention period (2019) based on the date of admission. Intervention measures for reducing door to wire time were fully implemented towards the end of the interim period. There were no significant differences in the baseline characteristics of the 2 groups. Median door to puncture time was reduced from 57.5 minutes in the interim period to 46.0 minutes (P < .001) in the post-intervention period. Similarly, median door to wire time was shortened from 88.0 minutes to 63.5 minutes (P < .001). During the interim period, 24% of patients had a door to wire time of <60 minutes, compared to 40.67% of patients in the post-intervention period (P = .002). Multidisciplinary collaboration is an important strategy to reduce door to wire time for patients with STEMI, and may be implemented in suitable centers to improve patient care.


Introduction
Acute myocardial infarction (AMI) remains to be one of the leading causes of morbidity and mortality worldwide despite contemporary advances in medicine. [1]The incidence of AMI has increased over the past decades both globally and in China, and is projected to increase by a striking 200% from 2025 to 2050. [2]Further improvements in the management of patients with AMI are urgently required to improve clinical outcome. [2][5] Time to primary PCI is strongly associated with mortality risk of STEMI, and efforts to reduce door to balloon time will improve patient outcome. [6]Accordingly, a door to balloon time of 90 minutes or less are recommended by current clinical guidelines on PCI. [4,7] and WL contributed to this article equally.
This study was supported by Foshan Sanshui Key Discipline.
Importantly, recent studies have suggested that physician-led triage strategies may be effective in shortening door-to balloon time for patients with STEMI. [8,9]In the present study, whether implementation of multidisciplinary collaboration strategies may further reduce door to wire time for STEMI patients undergoing PCI is investigated.
Objective: The aim of this study is to reduce door-to-wire time for ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention through multidisciplinary collaboration.

Methods
Patients over the age of 18 who visited the Foshan Sanshui District People's Hospital and were diagnosed with STEMI between 2018 and 2019 were included in this study.Patients who were diagnosed with in-hospital STEMI were excluded from this study.
Foshan Sanshui District People's Hospital is a tertiary medical center in Southern China, serving a population of >800,000 people.Patients included in the study were segregated based on the date of presentation into a preintervention interim period in 2018 prior to the full implementation of intervention measures, and a post-intervention period in 2019.The data used in this study were collected from the China National Chest Pain Platform and hospital medical records.

Statistical analysis
Statistical analyses were performed using BM SPSS version 27 (IBM, Armonk).Results were presented as means with the corresponding standard deviations and compared by the Student t test, or reported as medians along with the inter-quartile range (IQR) where the nonparametric Mann-Whitney U test was utilized.The chi-square test and Fisher's exact test were used for proportions.A P value of <.05 was considered statistically significant.

Intervention measures
In attempt to shorten door to wire time, the following interventions were implemented: 1. Logistical organization and arrangements were made for all hospital employees to learn the relevant requirements, regulations and guidelines of the chest pain center allowing all staff to indirectly or directly contribute to STEMI recognition and facilitate subsequent care.
Additional training sessions on recognizing chest pain as an urgent medical priority were also implemented for all new employees including those not directly involved in medical care such as cleaning staff, porters and security officers.Furthermore, regular training and teaching sessions were organized for staff in key departments of the chest pain center including the emergency department, cardiovascular medicine department, outpatient clinic, and catheterization laboratory to reinforce and further familiarize staff with the procedures for managing chest pain patients.2. Increased media coverage were sought to improve public awareness of the emergency medicine telephone number 120 (in China).In AMI, coronary arteries should be recanalized within 120 minutes from chest pain in order to maximally salvage the necrotic myocardium.Therefore, the importance of calling 120 as soon as possible if chest pain occurs was highlighted in particular to the general public.at the hospital entrance for patients with chest pain who come to the hospital on their own, and reminders to prioritize chest pain are placed throughout the emergency department.An ECG will be completed within 10 minutes after the first medical contact, and if STEMI is diagnosed, the catheterization lab will be notified immediately.At the same time, informed consent for PCI will be sought, and blood will be drawn to check troponin.7.For patients with chest pain who have received prehospital ECGs and subsequently confirmed to be STEMI, the following process was implemented with the aim to shorten door to wire time: immediately call the chest pain center for patient transfer, activate the catheterization laboratory as per protocol, and start acquiring informed consent for the procedure wherever feasible.8.For patients being transferred for PCI, the catheterization laboratory is activated as per protocol in the ambulance, and informed consent for the procedure is started.9. Further training for emergency department and cardiovascular physicians on informed consent skills were provided, allowing them to explain the condition and the necessity of emergency PCI as quickly as possible to patients and families, and allowing them to make informed decisions.10.Arrangements have been made for the catheterization laboratory to always have coronary surgery kits stocked, in order to avoid unnecessary delays upon patient arrival.11.The Chest Pain Center has a designated full-time data clerk to summarize the timeline of each STEMI patient accurately.A running quality analysis meeting and a chest pain case discussion meeting are held every 2 months to analyze the causes of door to wire overtime cases and make improvements accordingly to reduce the number of breaches.12.The Chest Pain Center telephone line is open 24 hours a day and is held by the chief resident of the Department of Cardiovascular Medicine to ensure immediate consultation, clear diagnosis and activation of the catheterization laboratory.13.A special incentive mechanism was implemented to reward staff and improve morale for every door to wire case that met the standards.
Comparisons of the interim and post-intervention periods are depicted in Table 1.A total of 305 STEMI patients were initially identified in the study, with 5 excluded as they were in-hospital STEMI cases.The patients were classified into the interim period (2018) and post-intervention period (2019) based on date of presentation, and there were no significant differences in baseline characteristics including age, gender, atrial fibrillation, stroke history, hyperlipidemia, hypertension, diabetes and PCI history between the 2 groups.Overall, there www.md-journal.comwas no difference in terms of in-hospital mortality between the 2 groups.
Time Trends of the interim and post-intervention periods are shown in Table 2.The median door to puncture time was reduced from 57.5 minutes in the interim period to 46.0 minutes (P ＜ .001) in post-intervention period.Similarly, median door to wire time was shortened from 88.0 minutes to 63.5 minutes (P ＜ .001).Strikingly, 24% of patients had a door to wire time of ≤60 minutes in the interim period, which is significantly lower than the 40.67% in the post-intervention period (P = .002).

Discussion
The present study demonstrates that door to wire time for STEMI patients undergoing PCI can be significantly reduced through the implementation of changes based on the principles of multidisciplinary collaboration.
[12] Similar to stroke, [10] early treatment is crucial to improve outcome in AMI patients, [13] and longer symptom to recanalization time is associated with increased infarct size and poor prognosis. [13]Achieving shorter time to PCI for STEMI patients remains a critical challenge, hampered by inconsistent access to catheterization labs particularly during out-of-hours. [14]Accordingly, the higher adjusted mortality rate associated with out-of-hours admissions for PCI can be partly explained by the longer reperfusion times. [15,16]linical and logistical factors that also contribute to longer reperfusion time in STEMI patients include prehospital delay, atypical presentations without chest pain, and absence of classical ECG findings of STEMI. [17]Transferred STEMI patients from another hospital face a longer time-to-PCI compared to those presenting directly to Chest Pain Centers with facilities for PCI, resulting in longer time to reperfusion and larger infarct sizes. [18]milarly, hemodynamic complications can result in longer time spent with the emergency medical services, further resulting in worse outcomes for STEMI patients.Emergency medical services delay time of STEMI patients should be closely monitored and reduced as appropriate. [19]n the other hand, it is important to recognize that overly aggressive measures to reduce door to wire time may be associated with an increased risk of false-positive diagnosis of STEMI. [20]Measures to reduce door to wire time should be monitored carefully to avoid unnecessary procedures, which are inherently associated with significant risks and in addition may result in the delay of more suitable therapies, especially for those that are critically ill. [20]Overall, the door to wire time involves many factors and a multidisciplinary collaborative approach serves as an important strategy to reduce door to wire time for STEMI patients and may improve clinical outcome.

Limitation
Limitations of this study include those inherently associated with a retrospective single-center study and future prospective research is required.

Conclusion
"Time is muscle" -multidisciplinary collaboration is an important strategy to reduce door to wire time for STEMI patients.The intervention measures adopted in this study are effective in reducing door to wire time and may be implemented by suitable centers with the potential to improve AMI patient outcome.
3. A Chest Pain Alliance WeChat work group was established to facilitate communication and improve time-todiagnosis from patient presentation.All alliance hospital units, chest pain center staff, and electrocardiogram (ECG) expert doctors were added to the group, allowing chest pain cases to be triaged and diagnosed remotely wherever possible, and enabling treatment recommendations to be made with minimal delay.

Table 1
Clinical comparison of interim and post-intervention periods.

Table 2
Time trends of interim and post-intervention periods.